A Case of Interstitial Pneumonia During Gemcitabine and Cisplatin Chemotherapy for Locally Advanced Bladder Cancer

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  • Matsumura, Eiri
    The Department of Urology, Graduate School of Medicine, University of the Ryukyus
  • Ashikari, Asuka
    The Department of Urology, Graduate School of Medicine, University of the Ryukyus
  • Tasaki, Shinsuke
    The Department of Urology, Graduate School of Medicine, University of the Ryukyus
  • Haranaga, Syusaku
    The Department of Infection・Respiratory・Digestive Internal Medicine, Graduate School of Medicine, University of the Ryukyus
  • Toyosato, Tomotsune
    The Department of Urology, Graduate School of Medicine, University of the Ryukyus
  • Ashimine, Satoshi
    The Department of Urology, Graduate School of Medicine, University of the Ryukyus
  • Machida, Noriko
    The Department of Urology, Graduate School of Medicine, University of the Ryukyus
  • Oshiro, Yoshinori
    The Department of Urology, Graduate School of Medicine, University of the Ryukyus
  • Saito, Seiichi
    The Department of Urology, Graduate School of Medicine, University of the Ryukyus

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Other Title
  • 局所進行性膀胱癌に対するGemcitabine-Cisplatin療法中に発症した間質性肺炎の1例
  • キョクショ シンコウセイ ボウコウガン ニ タイスル Gemcitabine Cisplatin リョウホウ チュウ ニ ハッショウ シタ カンシツセイ ハイエン ノ 1レイ

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Abstract

A 76-year-old woman received chemotherapy with gemcitabine and cisplatin (GC therapy) for local advanced bladder cancer. She suffered from dyspnea on day 19 during the first course of GC therapy. Both chest X-ray and computed tomography (CT) images revealed diffuse bilateral interstitial infiltrates. She was diagnosed as having drug-induced interstitial pneumonia. We identified gemcitabine as the causative agent based on the results of examinations (CT, X-ray, KL-6 level, drug lymphocyte stimulation test (DLST)). After three months of steroid therapy, her interstitial pneumonia was completely resolved on CT scans. Although gemcitabine-induced interstitial pneumonia is a rare adverse event, it should be considered a severe complication because delayed diagnosis and treatment can lead to a fatal outcome. Thus, early detection of drug-induced interstitial pneumonia is extremely important during GC therapy.

Journal

  • Hinyokika Kiyo

    Hinyokika Kiyo 57 (2), 81-85, 2011-02

    泌尿器科紀要刊行会

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