EFFECT OF PEPLEOMYCIN (BLEOMYCIN DERIVATIVE, NK 631) ON PROSTATIC CANCER

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Other Title
  • 前立腺癌に対するPepleomycin(Bleomycin Derivative, NK-631)の効果
  • 前立腺癌に対するPepleomycin(Bleomycin Derivative,NK-631)の効果〔英文〕
  • ゼンリツセンガン ニ タイスル Pepleomycin Bleomycin D

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Abstract

Since the new bleomycin derivative-pepleomycin was reported to be effective for experimentally induced adenocarcinoma of stomach in rats, it was administered in two cases of prostatic cancer. Satisfactory response was obtained in well differentiated carcinoma, meanwhile only histological effect was observed in undifferentiated one. It seems that the effect of pepleomycin on prostatic cancer was brought about by the suppression of DNA synthesis of tumor and also of pituitary function resulting in decreased androgen secretion from Leydig cells.

Journal

  • Hinyokika Kiyo

    Hinyokika Kiyo 26 (5), 629-637, 1980-05

    京都大学医学部泌尿器科学教室

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