A DOUBLE-BLIND COMPARISON OF THE EFFICACY OF CEFATRIZINE (S-640P) AND AMPICILLIN (AB-PC) IN URINARY TRACT INFECTION
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- Shishito, Sentaro
- Department of Urology, Tohohu University School of Medicine
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- Shibuya, Shozo
- Sendai Social Insurrance Hospital
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- Sasaki, Keiichi
- Department of Urology, Hachinohe City Hospital
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- Shibuya, Masayoshi
- Department of Urology, Hiraga General Hospital
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- Kato, Hiroaki
- Department of Urology, Okachi Central Hospita
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- Imabayashi, Kenichi
- Department of Urology, Tohohu University School of Medicine
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- Ozu, Keisuke
- Department of Urology, Kesennuma Public General Hospital
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- Ohnuma, Tetsutaro
- Department of Urology, Furukawa City Hospital
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- Kaiho, Hiroo
- Department of Urology, Tohoku Labour Accident Hospital
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- Sugawara, Keiji
- Department of Urology, Sendai Social Insurance Hospital
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- Nakano, Nobumichi
- Department of Urology, Sendai National Hospital
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- Kato, Masakazu
- Department of Urology, Sendai National Railway Hospital
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- Yamanaka, Masao
- Department of Urology, Nagai City Hospital
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- Nitta, Kiichi
- Department of Urology, Yamagata Prefecture Central Hospital
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- Matsushita, Shozaburo
- Department if Urology, Yonezawa City Hospital
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- Saito, Katsuyuki
- Department of Urology, Ohara General Hospital
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- Saito, Takeshi
- Department of Urology, Senjudo General Hospital
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- Miyata, Koyo
- Department of Urology, Iwaki Kyoritsu Hospital
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- Takeuchi, Mutsuo
- Department of Urology, Fukushima Labou Accident Hospital
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- Chiba, Ryuichi
- Department of Urology, Shirakawa Kosei General Hospital
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- Kurosawa, Masaya
- Department of Urology, Shizuoka Kosei Hospital
Bibliographic Information
- Other Title
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- 二重盲検法によるCefatrizine(S-640P)とAmpicillin(AB-PC)の尿路感染症に対する薬効比較
- ニジュウ モウケンホウ ニヨル Cefatrizine S 640P ト Am
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Abstract
Cefatrizine (S-640P, 1g/day, p.o.) and ampicillin (AB-PC, 1g/day, p.o.) were administered to 150 cases of acute urinary tract infections, and the efficacy of these drugs was compared with double blind procedure. Except 5 drop-out cases (2 in S-640P, and 3 in AB-PC), which had not visited the hospital after first administration of the drugs, the background of 145 cases were analyzed according to 33 articles, and it was to be satisfied in its uniformity as the subject of this trial. The final evaluation of therapeutic effect of each drug was decided according to the individual evaluation of the effect on urinary microorganism, urinary findings, and general status of the patients, except the side-effect. These results were analyzed statistically, and no significant difference was observed between these evaluations. Furthermore, x2-test, Wilcoxon's procedure, and calculation of several coefficients of correlation were carried out, but any significant difference between the action of these drugs could not be observed. As the side-effect, blister formation on the mucous membrane (1), exanthema (3), diarrhea (2), and slight increase of s-GOT and Al-P-ase (1) were observed in S-640P group; blister formation on mouth lip (1), decrease of neutrophilic leucocyte and increase of lymphocyte (1), exanthema (1), and increase of s-GOT, s-GPT and Al-P-ase (1) were found in AB-PC group. But all of these were slight and temporary, and these needed neither suspension of drug administration nor some available therapies. The clinical efficacy of S-640P was 74.0% on the 4th day of administration and 72.6% on the 8th day of administration, while the efficacy of AB-PC was 69.0% on the 4th day and 76.6% on the 8th day of administration. With the results obtained above, it was concluded that S-640P and AB-PC should have almost the same therapeutic effect on the simple acute urinary tract infections.
Journal
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- Hinyokika Kiyo
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Hinyokika Kiyo 21 (7), 681-703, 1975-07
京都大学医学部泌尿器科学教室
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Details 詳細情報について
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- CRID
- 1050282677154386560
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- NII Article ID
- 120002232963
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- NII Book ID
- AN00208315
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- ISSN
- 00181994
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- HANDLE
- 2433/121842
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- NDL BIB ID
- 1683966
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- Text Lang
- ja
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- Article Type
- departmental bulletin paper
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- Data Source
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- IRDB
- NDL
- CiNii Articles