Future Perspective in the Treatment of Urolithiasis Based on Oxalate Metabolism
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- Takayama, Tatsuya
- The Department of Urology, Hamamatsu University School of Medicine
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- Nagata, Masao
- The Department of Urology, Hamamatsu University School of Medicine
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- Mugiya, Soichi
- The Department of Urology, Hamamatsu University School of Medicine
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- Ozono, Seiichiro
- The Department of Urology, Hamamatsu University School of Medicine
Bibliographic Information
- Other Title
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- 蓚酸代謝関連酵素に尿路結石治療の未来を求めて (第59回日本泌尿器科学会中部総会)
- 蓚酸代謝関連酵素に尿路結石治療の未来を求めて
- シュウサン タイシャ カンレン コウソ ニ ニョウロ ケッセキ チリョウ ノ ミライ オ モトメテ
Search this article
Abstract
Urinary excretion of oxalate is one of risk factors in urinary stone formation. Prevention of undesirable overflow into the production of oxalate definitely leads to a decrease of urolithiasis. The activity of serine : pyruvate/alanine : glyoxylate aminotransferase (SPT/AGT) or glyoxylate reductase/hydroxypyruvate reductase (GRHPR), the key enzyme of primary hyperoxlauria type 1 and 2, respectively, and their subcellular distribution highly affects theoxalateproduction. On theothe r hand, urolithiasis is tightly related to lifestyle disease, such as diabetes mellitus and insulin resistance. The hypothesis that insulin resistance induces mitochondria dysfunction, resulting in the decrease of mitochondria-related enzyme activity is a very attractive new treatment strategy of urolithiasis. Namely, the improvement of insulin resistance might prevent stone formation.
Journal
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- Hinyokika Kiyo
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Hinyokika Kiyo 57 (1), 39-41, 2011-01
泌尿器科紀要刊行会
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Keywords
Details 詳細情報について
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- CRID
- 1050282677278187776
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- NII Article ID
- 120002770959
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- NII Book ID
- AN00208315
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- ISSN
- 00181994
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- HANDLE
- 2433/135434
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- NDL BIB ID
- 10955266
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- Text Lang
- ja
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- Article Type
- departmental bulletin paper
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- Data Source
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- IRDB
- NDL
- CiNii Articles