Study on the Syntheses and the Biological Activities of Fluorescent Labeled Analogs of Spider Toxin NPTX-594

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  • クモ毒NPTX-594の蛍光標識類縁体の合成と生物活性に関する研究
  • クモ ドク NPTX 594 ノ ケイコウ ヒョウシキ ルイエンタイ ノ ゴウセイ ト セイブツ カッセイ ニ カンスル ケンキュウ

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Abstract

The neurotoxic acylpolyamine NPTX-594 (1) was isolated from the venom of a Madagascar Joro spider. The toxin is comprised of four constituents, i.e., 2,4-dihydroxyphenylacetic acid (Dhpa), asparagine (Asn), 4,8-diaza-1,12-dodecanediamine (Dada) and lysine (Lys). Although spider toxins are known to be strong and specific blocker against the glutamate receptors (GluRs), the interaction between the toxins and the receptors has not been clarified yet. In order to confirm visually the complex formation between spider toxins and GluRs, the syntheses of several fluorescent labeled analogs of NPTX-594 were carried out. Furthermore, the biological activities of synthetic compounds are also described.

第42回ペプチド討論会(2005年10月, 大阪）にて一部発表 本文データの一部はCiNiiから複製したものである。

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