クモ毒NPTX-594の蛍光標識類縁体の合成と生物活性に関する研究

書誌事項

タイトル別名
  • Study on the Syntheses and the Biological Activities of Fluorescent Labeled Analogs of Spider Toxin NPTX-594
  • クモ ドク NPTX 594 ノ ケイコウ ヒョウシキ ルイエンタイ ノ ゴウセイ ト セイブツ カッセイ ニ カンスル ケンキュウ

この論文をさがす

抄録

The neurotoxic acylpolyamine NPTX-594 (1) was isolated from the venom of a Madagascar Joro spider. The toxin is comprised of four constituents, i.e., 2,4-dihydroxyphenylacetic acid (Dhpa), asparagine (Asn), 4,8-diaza-1,12-dodecanediamine (Dada) and lysine (Lys). Although spider toxins are known to be strong and specific blocker against the glutamate receptors (GluRs), the interaction between the toxins and the receptors has not been clarified yet. In order to confirm visually the complex formation between spider toxins and GluRs, the syntheses of several fluorescent labeled analogs of NPTX-594 were carried out. Furthermore, the biological activities of synthetic compounds are also described.

第42回ペプチド討論会(2005年10月, 大阪)にて一部発表 本文データの一部はCiNiiから複製したものである。

Departmental Bulletin Paper

application/pdf

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ