Synthetic Study of a Cardiac Steroid, Marinoic Acid

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  • 強心性ステロイド Marinoic acid の合成研究
  • キョウ シンセイ ステロイド Marinoic acid ノ ゴウセイ ケンキュウ

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Abstract

Marinoic acid (1), which is a novel bufadienolide-related substance in the skin of the giant toad (Bufomarinus), was isolated and the structure was determined by Akizawa et al. in 1996. Like bufadienolides, marinoic acid (1) contains an A/B ring structure in the cis configuration and a D/2-pyrone ring structure, but the structure of a C ring differed considerably from that of bufadienolides. Thus, marinoic acid (1) is an attractive synthetic target in view of the structural features as well as biological activity (Na^+, K^+-ATPase inhibitory activity). Herein synthetic approach towards the marinoic acid (1) with deoxycholic acid (2) as a starting material is described.

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