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説明
Double-strand breaks (DSBs) of DNA are introduced in neurons during embryonic brain development. Here I examine the DNA end joining activity to restore DSBs bearing distinct types of DNA ends in embryonic and adult brains. Embryonic brains contained the end joining activity for cohesive DNA ends. By contrast, adult brains showed no detectable end joining activity. The degree of the end joining activity seemed to be correlated with viability of neurons in culture. Thus, DNA repair for DSBs is likely to be involved in neuronal viability during brain development.
収録刊行物
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- 理工学総合研究所研究報告
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理工学総合研究所研究報告 (20), 27-33, 2008-02-01
近畿大学理工学総合研究所
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詳細情報 詳細情報について
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- CRID
- 1050282677522032768
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- NII論文ID
- 110007025716
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- NII書誌ID
- AN10074306
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- ISSN
- 09162054
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- NDL書誌ID
- 9405248
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- 本文言語コード
- en
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- NDL
- CiNii Articles