ネパールにおける遺伝性ヘモグロビンE(HbE)の解析

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  • ネパール ニ オケル イデンセイ ヘモグロビン E HbE ノ カイセキ
  • Analysis of hereditary hemoglobin E (HbE) in Nepal

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It has been suggested that a high frequency of abnormal hemoglobin might reflect an advantage due to a reduced susceptibility to malaria. To evaluate this malaria hypothesis, we analyzed abnormal hemoglobin in two neighboring populations of Nepal: the Danuwar and the Tamang. It was hypothesized that the settlements of the former were biologically adapted to the malarial environment, whereas those of the latter were customarily adapted. We detected nine heterozygotes for the β^E mutation generating HbE in four families in the Danuwar setllement by analysis of isoelectric focusing (IEF) and high performance liquid chromatography (HPLC).

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