PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE IS AN ESSENTIAL REGULATOR OF LYSOSOME MORPHOLOGY

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Abstract

Phosphoinositides are lipid second messengers that act as key players in endosomal membrane trafficking, and mutations in several phosphatases that metabolize these lipids cause severe genetic diseases. We previously reported that type III phosphatidylinositol phosphate kinase (PIPKIII) is a critical regulator of lysosome size. However, the lipid products that mediate PIPKIII function have not been well characterized. Using a series of phosphoinositide phosphatase expression vectors, we show here that phosphatidylinositol 3,5-bisphosphate is the obligatory lipid for lysosome morphology.

Journal

  • 秋田医学

    秋田医学 39 (3/4), 129-137, 2013-03-30

    秋田医学会

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