A HUMORAL LIPID PREVENTING FROM MOUSE ANAPHYLACTIC DEATH

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Description

Anaphylaxis gives mice severe stress killing them. They could produce adaptogenic substance for coping the stress. In the present study, the adaptogenic substance preventing from mouse anaphylactic death was examined. Six-week-old male ddY mice were initially immunized with 1 mg/kg of ovalbumin and second immunized with the same dosage 10 days after the initial immunization. The mice further immunized with the same dosage at 5 days or 15 days after the second immunization. All of the former were killed by the anaphylactic response, but none of the latter were. Although reactivity of fucosylated antibodies inducing anaphylactic response was not different in the former sera and the latter sera, a lipid preventing from anaphylactic death was found in fraction eluted with 300 mM NaCl of the latter sera. The present findings suggest that the lipid had an adaptogenic activity against severe stress induced by anaphylactic response, and was produced in late phase of the second immune response.

Journal

  • 秋田医学

    秋田医学 42 (1), 37-41, 2015-06-30

    秋田医学会

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