Identification of amino acids in antigen‐binding site of class II HLA proteins independently associated with hepatitis B vaccine response

DOI 機関リポジトリ 機関リポジトリ (HANDLE) Web Site Web Site ほか1件をすべて表示 一部だけ表示 被引用文献5件 参考文献35件 オープンアクセス

書誌事項

タイトル別名
  • Identification of amino acids in antigen-binding site of class II HLA proteins independently associated with hepatitis B vaccine response

この論文をさがす

説明

Genetic factors in class II human leukocyte antigen (HLA) have been reported to be associated with inter-individual variation in hepatitis B virus (HBV) vaccine response. However, the mechanism underlying the associations remains elusive. In particular, the broad linkage disequilibrium in HLA region complicates the localization of the independent effects of genetic variants. Thus, the present study aimed to identify the most probable causal variations in class II HLA loci involved in the immune response to HBV vaccine.We performed a case-control study to assess whether HLA-DRB1, -DQB1, and -DPB1 4-digit alleles were associated with the response to primary HBV vaccination in 574 healthy Japanese students. To identify causative variants, we next assessed independently associated amino acid variants in these loci using conditional logistic regression analysis. Furthermore, to clarify the functional effects of these variants on HLA proteins, we performed computational structural studies.HLA-DRB1HLA-DRβ1 position 26 and HLA-DPβ1 positions 84-87 are independently associated with anti-HBs production against HBV vaccine. Our results suggest that HBsAg presentation through these HLA pocket structures plays an important role in the inter-individual variability of HBV vaccination.

収録刊行物

  • Vaccine

    Vaccine 35 (4), 703-710, 2017-01

    Elsevier

被引用文献 (5)*注記

もっと見る

参考文献 (35)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ