Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder
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Previous studies have shown anti-inflammatory potential of alkaline extract of the leaves of Sasa senanensis Rehder (SE). The aim of the present study was to clarity the molecular entity of SE, using various fractionation methods. SE inhibited the production of nitric oxide (NO), but not tumour necrosis factor-α by lipopolysaccharide (LPS)-stimulated mouse macrophage-like cells. Lignin carbohydrate complex prepared from SE inhibited the NO production to a comparable extent with SE, whereas chlorophyllin was more active. On successive extraction with organic solvents, nearly 90% of SE components, including chlorophyllin, were recovered from the aqueous layer. Anti-HIV activity of SE was comparable with that of lignin-carbohydrate complex, and much higher than that of chlorophyllin and n-butanol extract fractions. The CYP3A inhibitory activity of SE was significantly lower than that of grapefruit juice and chlorophyllin. Oral administration of SE slightly reduced the number of oral bacteria. When SE was applied to HPLC, nearly 70% of SE components were eluted as a single peak. These data suggest that multiple components of SE may be associated with each other in the native state or after extraction with alkaline solution.
9p.
identifier:JOS-0258851X-24-735
収録刊行物
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- In Vivo : International Journal of Experimental and Clinical Pathophysiology of Drug Research
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In Vivo : International Journal of Experimental and Clinical Pathophysiology of Drug Research 24 (5), 735-743, 2010-09
International Institute of Anticancer Research
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詳細情報 詳細情報について
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- CRID
- 1050282677766388480
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- NII論文ID
- 120005518460
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- NII書誌ID
- AA10714348
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- ISSN
- 0258851X
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles