Low serum amylase in association with metabolic syndrome and diabetes: A community-based study

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Background: Low serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas.However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigatedwhether low serum amylase was associated with the pathogenesis of impaired insulin action: metabolic syndrome(MetS) and diabetes.Research Design and Methods: Serum amylase, cardiometabolic risk factors, MetS (Adult Treatment Panel IIIcriteria), and diabetes were examined in 2,425 asymptomatic subjects aged 30-80 years who underwent medicalcheckups recently (April 2009-March 2010) and 5 years ago.Results: Clinical variables, except for age and estimated glomerular filtration rate (eGFR), shifted favorably withincreasing serum amylase levels. Plasma glucose levels at 1- and 2-hr during OGTT increased significantly withdecreasing serum amylase levels. Multiple logistic analyses showed that, compared with highest quartile of serumamylase, lowest quartile was associated with increased risk for MetS and diabetes after adjustment for confoundingfactors [odds ratio (95% CI), 2.07 (1.39-3.07) and 2.76 (1.49-5.11), respectively]. In subjects who underwent checkups5 years ago (n = 571), lower amylase at the previous checkup were associated with larger numbers of metabolicabnormalities at the recent checkup. The fluctuation over time in serum amylase levels in subjects with low serumamylase at the previous checkup was slight and was unaffected by kidney dysfunction.Conclusions: Our results indicate that low serum amylase is associated with increased risk of metabolicabnormalities, MetS and diabetes. These results suggest a pancreatic exocrine-endocrine relationship in certainclinical conditions.

Licensee BioMed Central Ltd. This is an Open Access Article. 8p.

identifier:JOS-1475-2840-10-34

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