Mechanism of oxidative DNA damage by environmental chemicals and its role in carcinogenesis and aging

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  • 環境因子による酸化的DNA損傷とがん,老化 : 第12回公開シンポジウム : 活性酸素の分子病態学
  • 環境因子による酸化的DNA損傷とがん,老化
  • カンキョウ インシ ニ ヨル サンカテキ DNA ソンショウ ト ガン ロウカ

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Abstract

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Reactive oxygen species are capable of causing damage to various cellular constituents, such as DNA, proteins and lipids, leading to carcinogenesis, aging and a number of diseases. We have investigated the sequence specificity of oxidative stress-mediated DNA damage by using ^<32>P-labeled DNA fragments obtained from the human c-Ha-ras-1, p53 and p16 genes. The sequence specificity of DNA damage plays the key role in the mutagenic process, and affects the mutation frequency. Therefore, investigation on sequence specificity of DNA damage would provide clues on the biological significance of DNA damage which in turn may be beneficial for cancer prevention strategy. Here we discuss the mechanisms and sequence specificity of DNA damage caused by various environmental chemicals and UVA-activated photosensitizers in relation to carcinogenesis and aging.

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