ラット褐色脂肪組織に対する後肢ギプス固定の影響

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  • ラット カッショク シボウ ソシキ ニ タイスル コウシ ギプス コテイ ノ エイキョウ
  • Effects of Cast Immobilization on Brown Adipose Tissues in Rats

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We studied the effects of hind limb cast immobilization on brown adipose tissues in 14 male mature Sprague? Dawley rats (8 -weeks -old). The animals were divided into the following two groups: sedentary control (S; n = 7) and cast -immobilized (CAS; n = 7) groups. Animals in the CAS group were immobilized at the knee and foot joints for 10 days. Interscapular brown adipose tissue (IBAT) was isolated after 10 days of immobilization and weighed. In addition， IBAT lipid and protein content were measured. IBAT weight and relative IBAT weight in the CAS group were not significantly different from those in the S group.No statistical differences were found between the two groups for protein concentration or protein content of IBAT. However， significant correlations were observed among IBAT weight， protein concentration (negative， r = -0.702) and protein content (positive， r = 0.863). IBAT lipid concentration did not differ significantly between the two groups. However， IBAT lipid content was significantly lower in the CAS group than in the S group. A significant positive correlation was observed between IBAT weight and the lipid content (r = 0.904). These results indicate that the amount of lipid decreased in IBAT independent of protein content during cast immobilization.

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