Transchondroid Bone Formation Displayed in BMP-Induced Heterotopic Osteogenesis

機関リポジトリ NDLデジタルコレクション Web Site 被引用文献3件 参考文献15件

書誌事項

タイトル別名
  • 骨形成蛋白(BMP)誘発異所性骨形成において表示されたtranschondroid bone formation

この論文をさがす

抄録

application/pdf

It has been stated that BMP induces undifferentiated mesenchymal cells to become chondrocytes in the first stage of the BMP-induced heterotopic osteogenesis. The cartilage is replaced by bone in a manner similar to that in normal endochondral (indirect) ossification. It is suggested that the BMP induced-bone occurs through an endochondral-like ossification; however the cell differentiation patterns differ from those of the normal fetal endochondral ossification process. On the other hand, intramembranous (direct) ossification is observed in some cases. Therefore, we examined histopathologically the nature of the BMP induced heterotopic osteogenesis, that is, examining histological features that are more like bone than cartilage but whose cells were not distinguishable from chondrocytes. Round chondrocytes-like cells and smaller osteocytelike cells coexisted in the chondroid bone matrix. Furthermore, there were some chondroid patterns that still remained in the maturing bone matrix showing mosaic patterns. These findings seems to be a third ossification pattern, "transchondroid bone formation" , which was described by Yasui et al. (1997)11) in an experimentally distraction osteogenesis model in the rat. "Chondroid bone", a tissue intermediate between bone and cartilage, was formed mainly in BMP-induced heterotopic osteogenesis.

収録刊行物

  • Journal of Hard Tissue Biology

    Journal of Hard Tissue Biology 7 (1), 21-26, 1998-06

    Society for Hard Tissue Regenerative Biology (硬組織再生生物学会)

被引用文献 (3)*注記

もっと見る

参考文献 (15)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ