書誌事項
- タイトル別名
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- Alternative Antiandrogen Therapy with Flutamide in Patients with Castration-Resistant Prostate Cancer : A Single Center Experience
- キョセイ テイコウセイ ゼンリツセンガン ニ タイスル Flutamide オ モチイタ アンチアンドロゲン コウタイ リョウホウ
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Alternative Antiandrogen Therapy with Flutamide in Patients with Castration-Resistant Prostate Cancer : A Single Center Experience We analyzed the clinical effects of flutamide (FLT) as a second-line agent for maximum androgen blockade (MAB) in patients with castration-resistant prostate cancer who received bicalutamide (BCL) as the first-line MAB agent. This study included 44 cases with progressive prostate cancer who had relapsed after first-line MAB, with BCL at 80 mg/day. After checking for antiandrogen withdrawal syndrome (AWS), they were given FLT at 375 mg/day as second-line MAB. A partial response (prostate-specific antigen [PSA] decline ≧50%) and no change (PSA decline of 0-50% or increase <25%) by second-line MAB with FLT were achieved in 34.1% (15/44) and 25.0% (11/44), respectively. The median duration of PSA response was 8.2+/−4.5 months. In multivariate analysis, Gleason score (≦7 vs ≧8), the first-line response (CR vs PR+NC), and the second-line response (PR+NC vs PD) were significantly predictive of cause-specific survival from first-line hormonal therapy relapse to cancer death. Our results confirm previous findings that alternative antiandrogen therapy is effective as a second-line hormonal therapy.
収録刊行物
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- 泌尿器科紀要
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泌尿器科紀要 57 (6), 291-295, 2011-06
泌尿器科紀要刊行会
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詳細情報 詳細情報について
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- CRID
- 1050282810697424768
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- NII論文ID
- 40018861640
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- NII書誌ID
- AN00208315
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- ISSN
- 00181994
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- HANDLE
- 2433/143307
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- NDL書誌ID
- 11134090
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- 本文言語コード
- ja
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- NDL
- CiNii Articles