Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels
Bibliographic Information
- Other Title
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- Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumor blood vessels
Description
Tumour recurrence frequently occurs after radiotherapy, but the characteristics, intratumoural localization and post-irradiation behaviour of radioresistant cancer cells remain largely unknown. Here we develop a sophisticated strategy to track the post-irradiation fate of the cells, which exist in perinecrotic regions at the time of radiation. Although the perinecrotic tumour cells are originally hypoxia-inducible factor 1 (HIF-1)-negative, they acquire HIF-1 activity after surviving radiation, which triggers their translocation towards tumour blood vessels. HIF-1 inhibitors suppress the translocation and decrease the incidence of post-irradiation tumour recurrence. For the first time, our data unveil the HIF-1-dependent cellular dynamics during post-irradiation tumour recurrence and provide a rational basis for targeting HIF-1 after radiation therapy.
Journal
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- Nature Communications
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Nature Communications 3 1-10, 2012-04-17
Nature Publishing Group
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Details 詳細情報について
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- CRID
- 1050282810708564736
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- NII Article ID
- 120004007582
- 20000621879
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- ISSN
- 20411723
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- HANDLE
- 2433/155045
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- Crossref
- CiNii Articles
- KAKEN
