A novel detection technique of polyamide binding sites by photo-induced electron transfer in (Br)U substituted DNA

HANDLE Open Access
  • A, Saha
    Department of Science, Graduate School of Science, Kyoto University
  • F, Hashiya
    Department of Science, Graduate School of Science, Kyoto University
  • S, Kizaki
    Department of Science, Graduate School of Science, Kyoto University
  • S, Asamitsu
    Department of Science, Graduate School of Science, Kyoto University
  • K, Hashiya
    Department of Science, Graduate School of Science, Kyoto University
  • T, Bando
    Department of Science, Graduate School of Science, Kyoto University
  • H, Sugiyama
    Department of Science, Graduate School of Science, Kyoto University・Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University

Abstract

We report the photochemistry of (Br)U substituted DNA as a versatile platform to investigate the binding sites of pyrene conjugated pyrrole imidazole polyamides (PIPs). The results suggest that the approach can be used on a routine basis for the screening of polyamide binding sites.

Journal

Details 詳細情報について

  • CRID
    1050282810834197504
  • NII Article ID
    120006462491
  • ISSN
    13597345
  • HANDLE
    2433/230919
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • IRDB
    • CiNii Articles

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