Cytotoxic actions of lidocaine at sublethal concentrations : A model in vitro experiment using rat thymocytes
この論文をさがす
抄録
In order to reveal some cytotoxic features of lidocaine, the effects of lidocaine at sublethal concentrations (10 mM or less) on rat thymocytes were examined by the use of flow-cytometric technique with fluorescent probes. Treatment with lidocaine at 3-10 mM for 1-3 hr significantly increased intracellular Ca2+ and Zn2+ concentrations under normal condition. After the removal of external Ca2+ and Zn2+, lidocaine still increased intracellular Ca2+ and Zn2+ concentrations, suggesting the lidocaine-induced release of intracellular Ca2+ and Zn2+. Treatment with lidocaine at 0.3-1 mM for 24 hr significantly increased the populations of dead cells and shrunken cells. Lidocaine at sublethal concentrations exerts some cellular actions that are supposed to be linked to the cytotoxicity. The mechanism of lidocaine-induced cell death varies in time- and concentration-dependent manners.
収録刊行物
-
- 徳島大学総合科学部自然科学研究 = Natural Science Research, The University of Tokushima
-
徳島大学総合科学部自然科学研究 = Natural Science Research, The University of Tokushima 24 (1), 1-5, 2010-01-31
徳島大学.総合科学部
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1050282812440410752
-
- NII論文ID
- 110008703785
-
- NII書誌ID
- AN10065859
-
- ISSN
- 09146385
-
- NDL書誌ID
- 023446492
-
- 本文言語コード
- en
-
- 資料種別
- departmental bulletin paper
-
- データソース種別
-
- IRDB
- NDL
- CiNii Articles