Urinary Metabolites of Valproic Acid in Epileptic Patients

IR

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  • てんかん患者の尿中バルプロ酸代謝物

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6人のてんかん患者の尿中バルプロ酸濃度及びその代謝物(3-ケト体、3-ヒドロキシ体、グルクロン酸抱合体)をガスクロマトグラフー質量分析法により同時定量した。バルプロ酸を大量に服用している患者(2名)では、尿中のグルクロン酸抱合体の排泄量が顕著に増大していた。

The urinary excretion of valproic acid (VPA) and its metabolites (3-keto VPA, 3-OH VPA, and VPA-glucuronide) in 6 epileptic patients was studied using gas chromatography-mass spectrometry. The amount of VPA and 3-OH VPA excreted in the urine was low (0.1 - 0.5 % of the dose of VPA and 0.6 - 1.5 % of the dose of 3-OH administered). The amount of 3-keto VPA and glucuronide (VPA-Glu) excreted was marked (5.8 - 26.2 % and 13.1 - 88.7 % of the dose of VPA administered, respectively). The urinary excretion of VPA and its metabolites by patients who have taken a normal amount of a VPA preparation was almost the same as that of healthy volunteers. Two epileptic patients who took a large amount of the VPA preparation showed a high excretion of VPA-Glu without an increase in their plasma VPA-Glu.

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