Differential Involvement of μ1-Opioid Receptor on the Antinociception Induced by Dermorphin Tetrapeptide Analogues, Tyr-D-Arg-Phe-β-Ala and Tyr-D-Arg-Phe-β-Ala-NH_2
Bibliographic Information
- Other Title
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- Dermorphin tetrapeptide誘導体Tyr-D-Arg-Phe-β-AlaおよびTyr-D-Arg-Phe-β-Ala-NH_2の鎮痛作用発現におけるμ1受容体の関与
- Dermorphin tetrapeptide ユウドウタイ Tyr D Arg Phe ベータ Ala オヨビ Tyr D Arg Phe ベータ Ala NH2 ノ チンツウ サヨウ ハツゲン ニ オケル ミュー 1 ジュヨウタイ ノ カンヨ
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Abstract
Involvement of μ1-opioid receptor on the antinociception induced by dermorphin tetrapeptide analogues Try-D-Arg-Phe-β-Ala (TAPA) and Tyr-D-Arg-Phe-β-Ala-NH_2 (TAPA-NH_2) were determined in mice, using a tail-pressure test and formalin test. TAPA and TAPA-NH_2 injected i. c. v. and i. t. produced dose-dependent antinociception in both assays. In the tail-pressure test, the antinociception induced by i. c. v. and i. t. injected TAPA, but not TAPA-NH_2, was significantly attenuated by the pretreatment with naloxonazine, selective antagonist for μ1-opioid receptor. Moreover, naloxonazine also significantly attenuated the antinociception induced by i. c. v. injected TAPA, but not TAPA-NH_2 in formalin test. In contrast, the antinociception induced by both TAPA and TAPA-NH_2 given i. t. was significantly attenuated by the pretreatment with naloxonazine in formalin test. The present results suggest that TAPA and TAPA-NH_2 should be considered to be selective agonist for μ1-and μ2-opioid receptors, respectively. The C-terminal amidation may be the critical portion for TAPA-NH_2 to distinguish μ1-and μ2-opioid receptors.
Journal
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- Journal of Tohoku Pharmaceutical University
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Journal of Tohoku Pharmaceutical University (50), 173-178, 2003-12
仙台 : 東北薬科大学
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Details 詳細情報について
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- CRID
- 1050282812579702656
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- NII Article ID
- 120005549141
- 110004686350
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- NII Book ID
- AA1149311X
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- ISSN
- 1345157X
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- NDL BIB ID
- 7136604
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- Text Lang
- ja
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- Article Type
- departmental bulletin paper
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- Data Source
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- IRDB
- NDL
- CiNii Articles