Fluvoxamine ameliorates cognitive dysfunctions in olfactory bulbectomized mice

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  • 嗅球摘出マウスの認知障害に対するフルボキサミンの改善作用
  • キュウキュウ テキシュツ マウス ノ ニンチ ショウガイ ニ タイスル フルボキサミン ノ カイゼン サヨウ

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This study was undertaken to examine the effect of the selective serotonin reuptake inhibitor（ssRi）fluvoxamine on cognitive dysfunctions in olfactory bulbectomized（OBX）mice. in the novel object recognition test, OBX mice significantly decreased the exploratory preference in the retention session, but not in the training session. OBX-induced cognitive dysfunctions were significantly improved by chronic（3-week）administration of fluvoxamine（30 mg/kg/day）, but not acute. The present study suggests that chronic fluvoxamine treatment may ameliorate OBX-induced cognitive dysfunctions via a mechanism involving enhancement of synaptic plasticityrelated signaling. Therefore, ssRi such as fluvoxamine would be potential therapeutic drugs for the treatment of the cognitive dysfunctions of alzheimer s disease.

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