Bibliographic Information
- Other Title
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- マウスにおける 2,5,2', 5'-Tetrachlorobiphenyl の代謝に及ぼすフェノバルビタールの影響(B. 生活科学)
- マウス ニ オケル 2 5 2 5 Tetrachlorobiphenyl ノ
- Effects of Phenobarbital on the Metabolism of 2,5,2′, 5′-Tetrachlorobiphenyl in Mice (B. LIVING SCIENCE)
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Abstract
Effects of phenobarbital (PB), a potent inducer of microsomal drug-metabolizing enzymes, on the levels of metabolites of 2,5,2', 5'-tetrachlorobiphenyl (TCB) were studied in mice. Pretreatment of mice with PB (100mg/day/kg body weight) for 3 days before administration of a single dose of 2,5,2', 5'-TCB (8mg/mouse) resulted in 40 and 60% decreases of unchanged TCB in feces and whole-body tissues, respectively. The fecal extretion of methylthio-2,5,2', 5'-TCB's, which did not show any accumulation in tissues, was increased about 3 times the control value, whereas no alteration of the levels of methylsulfonyl-2,5,2', 5'-TCB's were observed in both feces and tissues. This marked increase in the level of methythio-TCB's is suggestive of the participation of microsomal drug-metabolizing enzymes in the formation of these metabolites. PB-pretreatment also resulted in a 40% increase in the fecal excretion of 3-hydroxy-2,5,2', 5'-TCB.
Journal
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- The scientific reports of the Kyoto Prefectural University. Natural science and living science
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The scientific reports of the Kyoto Prefectural University. Natural science and living science 28 37-43, 1977-11-30
京都 : 京都府立大学学術報告委員会
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Details 詳細情報について
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- CRID
- 1050282812603651072
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- NII Article ID
- 110000058029
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- NII Book ID
- AN00062300
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- NDL BIB ID
- 1916806
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- ISSN
- 0075739X
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- Text Lang
- ja
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- Article Type
- departmental bulletin paper
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- Data Source
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- IRDB
- NDL
- CiNii Articles