細菌およびヒト培養細胞に対するデヒドロ酢酸ナトリウムの影響

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  • 細菌およびヒト培養細胞に対するデヒドロ酢酸ナトリウムの影響(B. 生活科学)
  • サイキン オヨビ ヒト バイヨウ サイボウ ニ タイスル デヒドロ サクサン
  • A Comparative Study on the Bacteriostatic and Cytotoxic Effects of Sodium Dehydroacetate (B. LIVING SCIENCE)

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The toxic effects on bacteria (E. coli and S. aureus) and cultured human FL-cells of sodium dehydroacetate (DHA-S), a food preservative used in Japan for cheese, butter, and margarine, were studied. 1. DHA-S in a concentration of 1% markedly inhibited the growth of both bacterial strains after 24hr in culture. In a concentration of 0.05%, the slightly depressed growth of both strains was observed after 6hr in culture, but no significant effect on S. aureus was observed after 24hr. 2. The growth of cultured FL-cells treated with 1% DHA-S for 5min was depressed to about 5% of control at 5days after treatment. Treatment with 0.05% DHA-S had no detectable effect on the growth of FL-cells. 3. The morphologic effects of 1% DHA-S on Fl-cells were degenerative changes such as swelling of mitochondrion and fragmentations of nuclear envelope and plasma membrane.

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