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Vibrio cholerae embraces two major evolutionary traits as revealed by targeted gene sequencing
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- Okada, Kazuhisa
- Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI)･Research Institute for Microbial Diseases, Osaka University
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- Wongboot, Warawan
- Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI)
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- Chantaroj, Siriporn
- National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi
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- Natakuathung, Wirongrong
- Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI)
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- Roobthaisong, Amonrattana
- Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI)
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- Kamjumphol, Watcharaporn
- Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI)
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- Maruyama, Fumito
- Department of Microbiology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto
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- Takemura, Taichiro
- Vietnam Research Station, Institute of Tropical Medicine, Nagasaki University
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- Nakagawa, Ichiro
- Department of Microbiology, Kyoto University Graduate School of Medicine
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- Ohnishi, Makoto
- Department of Bacteriology, National Institute of Infectious Diseases, Tokyo
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- Hamada, Shigeyuki
- Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI), Nonthaburi･Research Institute for Microbial Diseases, Osaka University
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Description
Vibrio cholerae inhabits aquatic environments worldwide and has over 200 recognized serogroups classified by O-polysaccharide specificity. Here, we report that V. cholerae selects either of two genetic traits during their evolution. Sequencing of the specific gene locus MS6_A0927 revealed that 339 of 341 strains of V. cholerae and closely related Vibrio species originating from 34 countries over a century carried either metY (M) (~1, 269 bp) or luxR-hchA (LH) (~1, 600 bp) genes, and consequently those vibrios were separated into two clusters, M (45.4%) and LH (54.6%). Only two strains contained both M and LH in the same locus. Moreover, extensive polymorphisms in those genes were detected in M and LH with 79 and 46 sequence variations, respectively. V. cholerae O1 strains isolated from cholera outbreaks worldwide, and some non-O1 strains evolving from O1 via exchange of genes encoding cell surface polysaccharides possessed LH alleles. Analysis of polymorphisms in the gene locus implicated a high degree of genetic diversity and identical subpopulations among the V. cholerae species.
Journal
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- Scientific Reports
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Scientific Reports 8 2018-01-26
Springer Nature
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Keywords
- Genotype
- Immunology
- Evolutionary biology
- Global Health
- Gene
- Microbiology
- Article
- Evolution, Molecular
- Agricultural and Biological Sciences
- Computational biology
- Endocrinology
- Cholera
- Biochemistry, Genetics and Molecular Biology
- Genetics
- Cluster Analysis
- Humans
- Vibrio cholerae
- Biology
- Immunological Responses in Aquatic Organisms
- Vibrio
- Immunology and Microbiology
- Dynamics and Pathogenesis of Cholera Bacteria
- Bacteria
- FOS: Clinical medicine
- Genetic Variation
- Life Sciences
- Sequence Analysis, DNA
- Global Burden of Foodborne Pathogens
- Genes, Bacterial
- FOS: Biological sciences
- Food Science
Details 詳細情報について
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- CRID
- 1050282813184590464
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- NII Article ID
- 120006539567
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- ISSN
- 20452322
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- HANDLE
- 2433/235196
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- PubMed
- 29374205
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
