書誌事項
- タイトル別名
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- The Anti-Tumor Effect of Cyclic Polylactate
- カンジョウ ジュウゴウ ニュウサン ノ ガン サイボウ ゾウショク ヨクセイ コウカ
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説明
A novel supramolecular oligomer, cyclic polylactate (CPL), was originally discovered in the culture medium of tumor cells. CPL suppresses the growth of tumor cells by inhibiting the activities of enzymes involved in the glycolytic pathway, pyruvate kinase and lactate dehydrogenase. Application of CPL was found to induce apoptosis in tumor cells through 7A6 antigen expression and DNA ladder formation. In addition, CPL is reported to prolong significantly the survival period of tumor bearing mice. These findings suggest that CPL might be a useful chemotherapeutic agent for cancers.
収録刊行物
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- 長崎国際大学論叢
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長崎国際大学論叢 10 239-248, 2010-03
長崎国際大学
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詳細情報 詳細情報について
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- CRID
- 1050282813198268544
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- NII論文ID
- 120005578652
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- NII書誌ID
- AA11766493
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- ISSN
- 13464094
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- NDL書誌ID
- 10718986
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- 本文言語コード
- ja
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- NDLサーチ
- CiNii Articles
- KAKEN
