Correlation Analysis between Thyroid-related Hormones and the Plasma Concentration of Amino Acids

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  • 甲状腺関連ホルモンと血漿アミノ酸濃度との相関解析

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Thyroid-related hormones（TRHs）are involved in the regulation of endocrine function and metabolic processes of the thyroid gland, and hyperthyroidism is known to cause tremors, weight loss, and excessive sweating. As a part of examining the relationship between TRHs and the metabolism of amino acid in the plasma, we analyzed the correlation between TRHs and plasma levels of amino acids using samples from seven healthy volunteers. We measured three types of TRHs: thyroid-stimulating hormone（TSH）, free triiodothyronine（FT３）, and free thyroxine（FT４）in addition to ３９ different amino acidsincluding the ２０ proteinogenic amino acids in the plasma collected from the healthy volunteers. We observed significant correlations between levels of taurine and FT４（p ＝ ０．０１８）, valine and FT４（p ＝０．０４３）, citrulline and TSH（p ＝０．０１１）, and hydroxyproline and TSH（p ＝０．０４９）. We also observed a correlation between the levels of citrulline and hydroxyproline（p＝０．００７９）. These results suggest that the interaction between citrulline and hydroxyproline may be involved in the plasma amino acid metabolism of TRHs.

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