ラット膝関節における肥満細胞の分布に関する組織化学的研究

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  • ラット シツカンセツ ニ オケル ヒマン サイボウ ノ ブンプ ニ カンスル ソシキ カガクテキ ケンキュウ
  • Histochemical Distribution of Mast cells in the Rat Knee Joint

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Mast cells are an integral part of the immunological surveillance system that acts together with other immune cells to mount specific reactions in response to an inflammatory insult. The purpose of this histochemical study was to determine the distribution of mast cells in the knee joint of a normal rat. Toluidine blue or alciane blue positive mast cells were found in the loose connective tissue of the knee joint such as the synovial membrane, the peripheral space of the tendon and the periosteum. In the synovial intima mast cells were present beneath the lining cell layer, which was composed of macrophage-like A cells and fibroblast-like B cells. Mast cells were also found around the blood vessels in the subintimal layer. In the whole mounted specimens of the synovial membrane network-like CGRP nerve fibers, which are the peripheral terminals of nociceptive afferent neurons, were present around the cluster of mast cells. These findings extend the importance of the co-location of mast cells with macrophage-like A cells in the synovial membrane. The distribution of mast cells closely associated to blood vessels and nociceptive afferent neurons indicates that mast cells may act as a cellular sensor in inflammation and immunity.

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