Pathophysiology of trauma-induced coagulopathy : disseminated intravascular coagulation with the fibrinolytic phenotype

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  • Pathophysiology of trauma‐induced coagulopathy: disseminated intravascular coagulation with the fibrinolytic phenotype

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In severe trauma patients, coagulopathy is frequently observed in the acute phase of trauma. Trauma-induced coagulopathy is coagulopathy caused by the trauma itself. The pathophysiology of trauma-induced coagulopathy consists of coagulation activation, hyperfibrino(geno)lysis, and consumption coagulopathy. These pathophysiological mechanisms are the characteristics to DIC with the fibrinolytic phenotype.

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