Anti-Keratin Autoantibodies and Lichenoid and Macular Amyloidosis

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Anti-Keratin autoantibodies were detected in sera from normal persons and lichen amyloidosus and macular amyloidosis patients. In cord blood, the IgM class antibody was significantly low. But the IgG antibody in cord blood was as high as that in mother's serum. This antibody titer was also seen as low in young mice. These findings support the hypothesis that antikeratin autoantibodies are produced during the course of aging and maturation. Since amyloid in lichenoid and macular amyloidosis has been suggested as deriving from degenerated epidermal keratinocytes, immunoglobulin deposits on amyloid were examined in the present study for their antibody specificity. Immunoglobulins on amyloid were eluted by using a citrate buffer, a glycine buffer, and a NaCl solution. Eluted IgG was demonstrated to react with 50 kd and/or 67 kd keratins. This finding further suggests that the amyloid protein has the antigenic determinant of keratin molecules.

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