Insulin-like growth factor-1 and its receptor in mouse pituitary glands
書誌事項
- タイトル別名
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- Insulin-Like Growth Factor-I and Its Receptor in Mouse Pituitary Glands
- Insulin-like growth factor-1 and its re
- Insulin-Like Growth Factor-l and Its Receptor in Mouse Pituitary Glands.
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Insulin-like growth factor-I (IGF-I) is produced in the liver and other peripheral tissues in response to growth hormone (GH) stimuli. IGF-I regulates diverse physiological functions in an autocrine and/or paracrine manner. IGF-I and IGF-I receptor (type-I receptor) are expressed in human and rat pituitary glands. However, the cell types of IGF-I-expressing cells and target cells of IGF-I in the pituitary glands are not known. The present study was aimed to identify the cell types of IGF-I-expressing cells and of its type-I receptor-expressing cells in mouse pituitary glands. In the mouse pituitary glands, IGF-I mRNA and IGF-I receptor mRNA were detected by reverse transcription-polymerase chain reaction (RT-PCR). IGF-I-expressing cells and its receptor-expressing cells were detected by non-radioisotopic in situ hybridization using mouse IGF-I cDNA and IGF-I receptor cDNA probes, and their cell types were immunocytochemically determined using antibodies raised against pituitary hormones. We found that somatotrophs expressed both IGF-I and IGF-I receptors, and some of corticotrophs expressed IGF-I receptors. Co-localization of IGF-I and GH in the same cultured pituitary cells was observed by dual-labelling immunocytochemistry. The present study demonstrated that pituitary IGF-I produced in somatotrophs regulated functions of somatotrophs and corticotrophs in an autocrine and/or paracrine manner.
収録刊行物
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- Zoological Science
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Zoological Science 15 (4), 573-579, 1998-08
Zoological Society of Japan
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詳細情報 詳細情報について
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- CRID
- 1050283687312453376
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- NII論文ID
- 110003323592
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- NII書誌ID
- AA10545874
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- ISSN
- 02890003
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- NDL書誌ID
- 4555875
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- NDL
- Crossref
- NDL-Digital
- CiNii Articles