細胞内鉄動態と酸化ストレス抵抗性

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タイトル別名
  • Iron Dynamics and Oxidative Stress Resistance
  • サイボウ ナイテツ ドウタイ ト サンカ ストレス テイコウセイ

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抄録

Iron is the most abundant metal in our body, and is very important for vital phenomena such as oxygen transport in red blood cells. iron is involved not only in oxygen transport but also in collagen, DNA, and ATP synthesis. Therefore, lack of iron has an adverse effect on the cellular level. in addition, it has been reported if iron is excessive, carcinogenesis, diabetes and neurodegenerative diseases may occur. it has been also reported the sensitivity tooxidative stress was changed by intracellular and mitochondrial iron dynamics. we will discuss about the mechanism of incorporation of iron into the body, uptake and reuse of iron in the cell and mitochondria iron metabolism because mitochondria are the main iron-utilizing organelles in the cell.

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