Hierarchical Cluster and Region of Interest Analyses Based on Mass Spectrometry Imaging of Human Brain Tumours
抄録
Imaging mass spectrometry (IMS) has been rarely used to examine specimens of human brain tumours. In the current study, high quality brain tumour samples were selected by tissue observation. Further, IMS analysis was combined with a new hierarchical cluster analysis (IMS-HCA) and region of interest analysis (IMS-ROI). IMS-HCA was successful in creating groups consisting of similar signal distribution images of glial fibrillaryacidic protein (GFAP) and related multiple proteins in primary brain tumours. This clustering data suggested the relation of GFAP and these identified proteins in the brain tumorigenesis. Also, high levels of histone proteins, haemoglobin subunit α, tubulins, and GFAP were identified in a metastatic brain tumour using IMS-ROI. Our results show that IMS-HCA and IMS-ROI are promising techniques for identifying biomarkers using brain tumour samples.
収録刊行物
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- Scientific Reports
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Scientific Reports (10), 5757-, 2020-04-01
Springer Nature
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詳細情報 詳細情報について
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- CRID
- 1050285299796815488
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- NII論文ID
- 120006823932
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- ISSN
- 20452322
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- HANDLE
- 10258/00010213
- 2433/250202
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- Crossref
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