Facile Synthesis of N-terf-Butyloxycarbonyl-O-benzyl-L-threonine

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  • Facile Synthesis of N tert Butyl oxycar

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Abstract

A facile procedure for the synthesis of N-tert-butyloxycarbonyl-O-benzyl-L-threonine derived from L-threonine is described. N-tert-Butyloxycarbonyl-O-benzyl-L-threonine is obtained in an excellent yield by the reaction of N-tert-butyloxycarbonyl-L-threonine with sodium hydride and benzyl bromide and subsequent saponification with sodium hydroxide. The procedure is simple and the reaction proceeds without observable racemization.

長崎大学教養部紀要. 自然科学篇. 1985, 26(1), p.53-56

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