マウスのカタレプシー簡易測定法

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  • Simple Screening Method for Measuring C
  • A SIMPLE SCREENING METHOD FOR MEASURING CATALEPSY IN MICE
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The catalepsy produced by bulbocapnine, perphenazine, and reserpine was studied using a simple new method. The apparatus was made as follows: a vertical pole was made from the wooden square timbers measuring 0.7cm wide, and an aluminium bar measuring 22cm long and 0.2cm in diameter was positioned at a height of 20cm between the timbers. The mouse was hung by the forearm in the center of the bar. The time difference was measured before and after medication that it took a mouse to travel across the bar from the hanging place to the vertical pole. Results of this experiment were analyzed by "t" and "chi-square" tests. The advantage of this method was that it differentiated between cataleptic and paralytic reaction produced by the drugs.

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