Hemodynamic changes in neonates born to mothers with Graves' disease

書誌事項

タイトル別名
  • Hemodynamics in newborns and Graves’ disease

抄録

Purpose: Cardiac insufficiency is a major morbidity in neonatal hyperthyroidism. It is important to assess the hemodynamics in neonates born to mothers with Graves’ disease (GD). This study prospectively evaluated the hemodynamic changes in neonates born to mothers with GD.Methods: Overall, 80 newborns were enrolled. Thirty-six neonates were born to mothers with GD who were positive for thyroid-stimulating hormone (TSH) receptor antibody (TRAb), and 44 were born to mother negative for TRAb. The serum levels of TSH, free triiodothyronine (FT3), free thyroxine (FT4), and N-terminal-pro-B-type natriuretic peptide (NT-proBNP), the cardiac output, and cardiac index (CI) evaluated by echocardiography were compared between the two groups at several postnatal points (day of delivery and 5, 10, and 30 days of life).Results: The TRAb-positive newborns had higher FT4 levels and CI on Day 5 (both p<0.05) and higher FT3 (p<0.05) and FT4 levels (p<0.01) and CI (p<0.01) but lower TSH levels (p<0.05) on Day 10 than the TRAb-negative newborns. The TRAb-positive newborns had significantly higher NT-proBNP levels on Days 5 (median 752 vs. 563 pg/mL, p=0.034) and 10 (median 789 vs. 552 pg/mL, p=0.002) than the TRAb-negative newborns.Conclusions: Hemodynamic changes in 1 neonates born to TRAb-positive mothers with GD resulted in a higher CI and NT-proBNP levels than in those with TRAb-negative mothers from postnatal days 5 to 10.

収録刊行物

  • Endocrine

    Endocrine 72 (1), 171-178, 2021-04

    Springer Nature

詳細情報

  • CRID
    1050290163806429568
  • NII論文ID
    120007169759
  • ISSN
    1355008X
    15590100
  • Web Site
    http://hdl.handle.net/10271/00003928
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB
    • CiNii Articles

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