魚類のウロコを用いた宇宙生物学的研究: 魚類のウロコにおけるホルモン応答

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  • Fish Scale Study for Space Biology: Hormonal Responses in the Fish Scale

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第26回宇宙利用シンポジウム(2010年1月25日-26日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス)

The Twenty-sixth Space Utilization Symposium (January 25-26, 2010: ISAS/JAXA Sagamihara, Japan)

Fish scale is a calcified tissue that contains osteoblasts, osteoclasts, and the bone matrix of two layers (a bony layer: a thin, well-calcified external layer; and a fibrillary layer: a thick, partially calcified layer), all of which are similar to those found in mammalian membrane bone. Recently, we developed a new in vitro model system using goldfish scales. This system can be used to detect the activities of osteoblasts and osteoclasts with alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) as respective markers. Therefore, it can be used to analyze the co-relationship between osteoblasts and osteoclasts. To obtain basic data for a space experiment, effects of calcemic hormones, such as parathyroid hormone (PTH), calcitonin, vitamin D3, and insulin-like growth factor-I on osteoblasts and osteoclasts in the scale, were examined using this assay in the present study. PTH activated osteoblastic activity and then increased osteoclastic activity. Furthermore, we found that other calcemic hormones function in both osteoclasts and osteoblasts in the fish scale as they do in mammals. Thus, scale is a functional calcium reservoir and has a physiological significance role in the bone metabolism of teleosts. Our assay system may help explain the mechanism of bone loss, such as that occurring during space flight.

共催: 日本学術会議

著者人数: 35人

joint hosting: The Science Council of Japan

資料番号: AA0064730077

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