模擬微小重力曝露後の骨代謝デコンディショニングに対する対抗措置の有効性

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  • Effectiveness of countermeasure to bone metabolic deconditioning induced by simulated microgravity exposure.

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第26回宇宙利用シンポジウム(2010年1月25日-26日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス)

The Twenty-sixth Space Utilization Symposium (January 25-26, 2010: ISAS/JAXA Sagamihara, Japan)

We investigated that artificial gravity and ergometric exercise as the countermeasure throughout -6 deg head-down bed rest (HDBR) for 20 days prevent bone metabolic deconditioning. Twelve healthy male subjects participated in this study. During the HDBR, 6 subjects performed ergometric exercise with artificial gravity for cumulative 30 min per day (countermeasure group), while 6 subjects underwent the same HDBR procedure without countermeasure (control group). In countermeasure group, urinary deoxypiridinorine (DPD) and crosslinked N-telopeptides of type I collagen (NTX) as an index of osteoclast activity were not significant difference between before and after HDBR, whereas it increased after HDBR in the control group. In control group, the increase of DPD was linearly related to the muscle sympathetic nerve activity. In conclusion, bone metabolic deconditioning after HDBR was prevented by countermeasure of everyday, and sympathetic nerve activity might be related to bone metabolism.

共催: 日本学術会議

著者人数: 15人

joint hosting: The Science Council of Japan

資料番号: AA0064730045

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