Microglial SIRPα regulates the emergence of CD11c
                  <sup>+</sup>
                  microglia and demyelination damage in white matter

Sato-Hashimoto, Miho, Kawamoto, Kyoko, Nozu, Tomomi, Toriba, Riho, Horikoshi, Ayano, Akaike, Miho, Nagai, Hiromi, Hirose, Ayaka, Hayashi, Yuriko, Shimizu, Wakana, Saiki, Ayaka, Ishikawa, Tatsuya, Jung, Steffen, Elhanbly, Ruwaida, 齊藤, 泰之, 的崎, 尚, Fukazawa, Yugo, Naruse, Masae, Shibasaki, Koji, Oldenborg, Per-Arne, 小谷, 武徳, 村田, 陽二, Ohnishi, Hiroshi

doi:10.1101/443531

Microglial SIRPα regulates the emergence of CD11c <sup>+</sup> microglia and demyelination damage in white matter

書誌事項

タイトル別名

Microglial SIRPα regulates the emergence of CD11c(+) microglia and demyelination damage in white matter
Microglial SIRPalpha regulates the emergence of CD11c(+) microglia and demyelination damage in white matter

公開日: 2019-03-26

資源種別: journal article

権利情報

Copyright Sato-Hashimoto et al.
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

DOI

10.7554/elife.42025
10.1101/443531

公開者: eLife Sciences Publications

説明

A characteristic subset of microglia expressing CD11c appears in response to brain damage. However, the functional role of CD11c(+) microglia, as well as the mechanism of its induction, are poorly understood. Here we report that the genetic ablation of signal regulatory protein α (SIRPα), a membrane protein, induced the emergence of CD11c(+) microglia in the brain white matter. Mice lacking CD47, a physiological ligand of SIRPα, and microglia-specific SIRPα-knockout mice exhibited the same phenotype, suggesting that an interaction between microglial SIRPα and CD47 on neighbouring cells suppressed the emergence of CD11c(+) microglia. A lack of SIRPα did not cause detectable damage to the white matter, but resulted in the increased expression of genes whose expression is characteristic of the repair phase after demyelination. In addition, cuprizone-induced demyelination was alleviated by the microglia-specific ablation of SIRPα. Thus, microglial SIRPα suppresses the induction of CD11c(+) microglia that have the potential to accelerate the repair of damaged white matter.

収録刊行物

eLife

eLife 8 e42025-e42025, 2019-03-26

eLife Sciences Publications

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Microglial SIRPα regulates the emergence of CD11c <sup>+</sup> microglia and demyelination damage in white matter

書誌事項

説明

収録刊行物

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Microglial SIRPα regulates the emergence of CD11c <sup>+</sup> microglia and demyelination damage in white matter

書誌事項

説明

収録刊行物

被引用文献 (4)*注記

参考文献 (57)*注記

関連プロジェクト

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書き出し

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