塞栓療法用懸濁液作成におけるプラスチック製三方活栓のリピオドールに対する耐久性の検討

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  • ソクセン リョウホウヨウ ケンダクエキ サクセイ ニ オケル プラスチックセイ サンボウ カッセン ノ リピオドール ニ タイスル タイキュウセイ ノ ケントウ
  • Evaluation of durability of three-way stopcocks to Lipiodol in making an emulsion for transcatheter arterial chemo-embolization

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【Objective】When we repeated pumping a mixture of Lipiodol and anticancer drugs between two syringes connected by a plastic material-made three-way stopcock to make an emulsion for transcatheter arterial chemo-embolization, we occasionally underwent leaks from the stopcock. A crack was found in the stopcock and it seemingly resulted from damages to the stopcock by Lipiodol. In this study, we examined the durability of three-way stopcocks to Lipiodol. 【Method】Three-way stopcocks made of four kinds of plastic material, polycarbonate, polypropylene, polyamide and polysulfone, were examined. First, we soaked these four kinds of stopcocks in Lipiodol for six hours and examined the emergence of damage. Next, we carried out pumping with the use of these stopcocks in a practical manner and examined the emergence of damage. 【Results】In soaking and pumping, a crack occurred only in three-way stopcocks made of polycarbonate, while no cracks were detected in other three-way stopcocks made of polypropylene, polyamide and polysulfone 【Conclusion】Lipiodol damaged three-way stopcocks made of polycarbonate and caused a crack and leak in pumping procedure. Three-way stopcocks made of polypropylene, polyamide and polysulfone were durable to Lipiodol and were recommended for use in making an emulsion for chemo-embolization

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