An increase in corrected QT interval may indicate a good clinical response to amitriptyline in female patients with burning mouth syndrome
書誌事項
- タイトル別名
-
- QTc in burning mouth syndrome
抄録
Burning mouth syndrome (BMS) is characterized by a burning sensation of the oral mucosa in the absence of underlying causes. BMS patients can pose a therapeutic challenge to clinicians. Amitriptyline has been a first-line treatment for BMS and is known to prolong corrected QT interval (QTc) in a dose dependent manner. However, little is known about the QTc lengthening effect of amitriptyline at analgesic dosages. The objective of this study was to evaluate changes in QTc in female BMS patients treated with amitriptyline. We conducted a single-center retrospective observational study and evaluated 40 female BMS patients. The QTc interval did not show statistically significant increase with amitriptyline (p=0.1502). However, the change in QTc of amitriptyline-responders was significantly longer than that of non-responders (p=0.0142). The change in QTc may be a non-invasive maker of clinical responses to amitriptyline in female BMS patients.
収録刊行物
-
- Neurology and Neurobiology
-
Neurology and Neurobiology 1 (1), 2018-07-22
Science Repository
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1050294562444024320
-
- ISSN
- 26137828
-
- 本文言語コード
- en
-
- 資料種別
- journal article
-
- データソース種別
-
- IRDB