Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations
抄録
Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin. Resistant C. auris with FKS1 mutations, including S639F, S639Y, D642Y, R1354H, or R1354Y, were isolated and found to be micafungin- and caspofungin-resistant in vivo; however, the MICs of isolates with mutation in R1354 remained below the micafungin breakpoint in vitro.
Antimicrobial agents and chemotherapy, 67(4), art. no. e0124322; 2023
収録刊行物
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- Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy 67 (4), e012432-, 2023-03-15
American Society for Microbiology
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詳細情報 詳細情報について
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- CRID
- 1050295989004519936
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- ISSN
- 00664804
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- HANDLE
- 10069/00042370
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB