Vertical Transmission of Coxsackievirus A6 with Severe Congenital Pneumonia/Sepsis
Abstract
We report a case of vertical transmission of Coxsackievirus (CV)-A6 with severe congenital pneumonia/sepsis. A male infant presented with severe respiratory symptoms at birth and was treated with full cardiopulmonary support, including inhaled nitric oxide. Three days before delivery, his older brother was diagnosed with hand, foot, and mouth disease (HFMD). His mother developed transient fever 1 day before delivery and presented a blister on her thumb 2 days after delivery. A multiplex polymerase chain reaction test on day 2 was positive for human rhinovirus/enterovirus. CV-A6 was later detected in the serum, tracheal aspirate, and stool of the patient sampled on day 6, and in the maternal serum sampled on the day of delivery. He was diagnosed with congenital CV-A6 pneumonia/sepsis caused by vertical transmission, based on VP1 consensus sequences used for typing of the virus that demonstrated a 100% match between the mother and infant. Further, the strain was closely related to the lethal CV-A6-Changchun strains in the phylogenetic analysis of the P2 region, which contributes to the pathogenicity. In conclusion, congenital CV-A6 infection should be considered if a woman exhibits HFMD symptoms during the perinatal period. Detailed virologic examination is useful for understanding its pathogenesis.
Journal
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- International Journal of Environmental Research and Public Health
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International Journal of Environmental Research and Public Health 20 (4), 2843-, 2023-02
MDPI
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Details 詳細情報について
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- CRID
- 1050298975368404224
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- ISSN
- 16604601
- 16617827
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- HANDLE
- 20.500.14094/0100486180
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB