Partial Effects of Ascorbic Acid on Cytokine-Induced Oxidation Stress in Cultured Neurons.

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  • 培養神経細胞における炎症性サイトカイン誘発性活性酸素に対するビタミンC の効果
  • バイヨウ シンケイ サイボウ ニ オケル エンショウセイ サイトカイン ユウハツセイ カッセイ サンソ ニ タイスル ビタミン C ノ コウカ

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Abstract

Vitamin C (ascorbic acid) is an essential nutrient that cannot be synthesized in the human body. Although vitaminC is abundant in the body, including the brain, the mechanism by which it is distributed throughout the body is notfully understood. In particular, the brain has barrier mechanisms such as the blood-brain barrier that makes it difficult for water-soluble substances to pass through blood vessel in the brain, so elucidation of the transport mechanism of vitamin C is still awaited. Recently, the existence of a traverse cellular vitamin C transporter has been reported. We therefore focused on the antioxidant effects of vitamin C in the brain, since the brain maintains a relatively high level of vitamin C compared with other organs. We have investigated the production of reactive oxygen species (ROS) by administration of inflammatory cytokines and mainly the effects of fat-soluble antioxidants. In this study, we investigated the inhibition of reactive oxygen species induced by inflammatory cytokines using L-ascorbic acid, a water-soluble vitamin. ROS are produced in physiological conditions and are also actively generated in the body for biological defense. However, excessive ROS cause damage to cellular components in the body. We investigated how L-ascorbic acid affects ROS induced in cultured neurons by inflammatory cytokines, and found that L-ascorbic had either weak or partial effects on ROS production induced by several inflammatory cytokines.

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