Dietary epigallocatechin gallate worsens rat liver injury induced by a high‐fat diet and ethanol consumption

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  • エピガロカテキンガレートは高脂肪食とエタノール摂取によるラットの肝障害を悪化させる

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Heavy drinking and obesity, which often coexist, have been shown to promote liver injury, steatohepatitis, and fibrosis developments. The recent increase in the incidence of metabolic syndrome highlights the potential of heavy drinking and obesity to cause liver damage and consequent inflammation synergistically. Tea is consumed worldwide. Catechin, a bitter tea component, is a polyphenol. Catechins have many physiological effects, including antioxidant, bactericidal, anticancer, hypotensive, cholesterol‐lowering, and blood sugar‐suppressing effects. Recently, it has been suggested that they exert anti‐obesity effects. This study investigated the effects of epicatechin gallate combined with a high‐fat diet and chronic alcohol consumption on liver damage in rats. Twenty male Wistar rats were randomized into four groups of five: control, high‐fat diet, high‐fat‐ethanol diet, and high‐fat‐ethanol‐epicatechin gallate diet groups. The rats in each group were fed the experimental diets ad libitum for eight weeks. High‐fat diet and ethanol consumption induced fatty liver in rats. Additionally, epicatechin gallate exacerbated liver injury. However, epicatechin gallate content in normal green tea intake is considered safe, and caution should be exercised when consuming concentrated supplements.

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