Immune tolerance caused by repeated P. falciparum infection against SE36 malaria vaccine candidate antigen and the resulting limited polymorphism
説明
Palacpac N.M.Q., Ishii K.J., Arisue N., et al. Immune tolerance caused by repeated P. falciparum infection against SE36 malaria vaccine candidate antigen and the resulting limited polymorphism. Parasitology International 99, 102845 (2024); https://doi.org/10.1016/j.parint.2023.102845.
The call for second generation malaria vaccines needs not only the identification of novel candidate antigens or adjuvants but also a better understanding of immune responses and the underlying protective processes. Plasmodium parasites have evolved a range of strategies to manipulate the host immune system to guarantee survival and establish parasitism. These immune evasion strategies hamper efforts to develop effective malaria vaccines. In the case of a malaria vaccine targeting the N-terminal domain of P. falciparum serine repeat antigen 5 (SE36), now in clinical trials, we observed reduced responsiveness (lowered immunogenicity) which may be attributed to immune tolerance/immune suppression. Here, immunogenicity data and insights into the immune responses to SE36 antigen from epidemiological studies and clinical trials are summarized. Documenting these observations is important to help identify gaps for SE36 continued development and engender hope that highly effective blood-stage/multi-stage vaccines can be achieved.
収録刊行物
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- Parasitology International
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Parasitology International 99 102845-, 2024-04-01
Elsevier Ireland Ltd
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詳細情報 詳細情報について
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- CRID
- 1050299693922528768
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- ISSN
- 18730329
- 13835769
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- HANDLE
- 11094/94028
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB