Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells
説明
The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Recent studies including single-cell transcriptomic analyses have highlighted a rich diversity in functional mTEC subpopulations. Because of their limited cellularity, however, the biochemical characterization of TECs, including the proteomic profiling of cTECs and mTECs, has remained unestablished. Utilizing genetically modified mice that carry enlarged but functional thymuses, here we show a combination of proteomic and transcriptomic profiles for cTECs and mTECs, which identified signature molecules that characterize a developmental and functional contrast between cTECs and mTECs. Our results reveal a highly specific impact of the thymoproteasome on proteasome subunit composition in cTECs and provide an integrated trans-omics platform for further exploration of thymus biology.
収録刊行物
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- Cell Reports
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Cell Reports 29 (9), 2901-2916, 2019-11-26
Elsevier
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詳細情報 詳細情報について
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- CRID
- 1050302172852406528
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- NII論文ID
- 120006894616
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- ISSN
- 22111247
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- 資料種別
- journal article
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- データソース種別
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