Deep learning approach using SPECT-to-PET translation for attenuation correction in CT-less myocardial perfusion SPECT imaging

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  • Kawakubo, Masateru
    Department of Health Sciences, Faculty of Medical Sciences, Kyushu University
  • Nagao, Michinobu
    Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University
  • Kaimoto, Yoko
    Department of Radiology, Tokyo Women’s Medical University
  • Nakao, Risako
    Department of Cardiology, Tokyo Women’s Medical University
  • Yamamoto, Atsushi
    Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University Department of Cardiology, Tokyo Women’s Medical University
  • Kawasaki, Hiroshi
    Department of Advanced Information Technology, Faculty of Information Science and Electrical Engineering, Kyushu University
  • Iwaguchi, Takafumi
    Department of Advanced Information Technology, Faculty of Information Science and Electrical Engineering, Kyushu University
  • Matsuo, Yuka
    Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University
  • Kaneko, Koichiro
    Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University
  • Sakai, Akiko
    Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University Department of Cardiology, Tokyo Women’s Medical University
  • Sakai, Shuji
    Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University

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Objective / Deep learning approaches have attracted attention for improving the scoring accuracy in computed tomography-less single photon emission computed tomography (SPECT). In this study, we proposed a novel deep learning approach referring to positron emission tomography (PET). The aims of this study were to analyze the agreement of representative voxel values and perfusion scores of SPECT-to-PET translation model-generated SPECT (SPECT_<SPT>) against PET in 17 segments according to the American Heart Association (AHA). / Methods / This retrospective study evaluated the patient-to-patient stress, resting SPECT, and PET datasets of 71 patients. The SPECT_<SPT> generation model was trained (stress: 979 image pairs, rest: 987 image pairs) and validated (stress: 421 image pairs, rest: 425 image pairs) using 31 cases of SPECT and PET image pairs using an image-to-image translation network. Forty of 71 cases of left ventricular base-to-apex short-axis images were translated to SPECT_<SPT> in the stress and resting state (stress: 1830 images, rest: 1856 images). Representative voxel values of SPECT and SPECT_<SPT> in the 17 AHA segments against PET were compared. The stress, resting, and difference scores of 40 cases of SPECT and SPECT_<SPT> were also compared in each of the 17 segments. / Results / For AHA 17-segment-wise analysis, stressed SPECT but not SPECT_<SPT> voxel values showed significant error from PET at basal anterior regions (segments #1, #6), and at mid inferoseptal regions (segments #8, #9, and #10). SPECT, but not SPECT_<SPT>, voxel values at resting state showed significant error at basal anterior regions (segments #1, #2, and #6), and at mid inferior regions (segments #8, #9, and #11). Significant SPECT overscoring was observed against PET in basal-to-apical inferior regions (segments #4, #10, and #15) during stress. No significant overscoring was observed in SPECT_<SPT> at stress, and only moderate over and underscoring in the basal inferior region (segment #4) was found in the resting and difference states. / Conclusions / Our PET-supervised deep learning model is a new approach to correct well-known inferior wall attenuation in SPECT myocardial perfusion imaging. As standalone SPECT systems are used worldwide, the SPECT_<SPT> generation model may be applied as a low-cost and practical clinical tool that provides powerful auxiliary information for the diagnosis of myocardial blood flow.

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