A matched set of frog sequences

DOI DOI 機関リポジトリ 機関リポジトリ HANDLE ほか4件をすべて表示 一部だけ表示 被引用文献94件 参考文献54件 オープンアクセス

書誌事項

タイトル別名
  • Genome evolution in the allotetraploid frog Xenopus laevis
公開日
2016-10-19
資源種別
journal article
DOI
  • 10.1038/nature19840
  • 10.1038/538320a
公開者
Springer Science and Business Media LLC

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説明

<p>To explore the origins and consequences of tetraploidy in the African clawed frog, we sequenced the Xenopus laevis genome and compared it to the related diploid X. tropicalis genome. We characterize the allotetraploid origin of X. laevis by partitioning its genome into two homoeologous subgenomes, marked by distinct families of 'fossil' transposable elements. On the basis of the activity of these elements and the age of hundreds of unitary pseudogenes, we estimate that the two diploid progenitor species diverged around 34 million years ago (Ma) and combined to form an allotetraploid around 17-18 Ma. More than 56% of all genes were retained in two homoeologous copies. Protein function, gene expression, and the amount of conserved flanking sequence all correlate with retention rates. The subgenomes have evolved asymmetrically, with one chromosome set more often preserving the ancestral state and the other experiencing more gene loss, deletion, rearrangement, and reduced gene expression.</p>

収録刊行物

  • Nature

    Nature 538 (7625), 336-, 2016-10-19

    Springer Science and Business Media LLC

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